18.06.2021

WHAT IS FUCOIDAN? (Part 3)

 WHAT IS FUCOIDAN? (Part 3)

3. Enhancement of immune system

Fucoidan also boosts the immune system. It has been seen that when fucoidan is consumed, the body is able to fight cancer better. Some research was conducted on mice to see the effect of fucoidan on immune system. The study showed that fucoidan restores the immune system in immunosuppressed mice and it functions as an immunomodulator and acts directly on T-lymphocyte. It was also found out that fucoidan helps in the recovery of immunologic functions in irradiated rats. The mechanism is similar to the arresting of lymphocyte by fucoidan. Fucoidan has also shown to increase the production of interferon-y and interleukin-1 in vitro and increases the functionality of T-lymphocyte. It was also seen that it promotes the antibody response to sheep red blood cells (SRBC) in the vivo. The high molecular weight fucoidan helps in the increase  in the promotion of murine cytotoxic T cells.

Different polysaccharides like fucoidan which has been obtained from different natural sources are biological response modifiers and increase the different immune responses. So, fucoidan directly stops the production of tumor cells in the body. Fucoidan also helps in the diffusion of the tumor cells and enhances the immunomodulatory activities of the body. The quantity of macrophages in the body is also increased due to fucoidan and helps in the destruction of tumor through the Type 1 T-helper cell. A research was conducted in 2003 which showed that fucoidan has anti-tumor properties in it (3).

 

4. Fucoidan against fatigue

A study was recently conducted in Tottori University in Japan which analyzed if fucoidan helps the patients from different anti-cancer drugs. Some of the common side effects of anti-cancerous drugs are vomiting, nausea, fatigue, diarrhea and bone marrow suppression. Peripheral neuropathy is specific for oxaliplation, which treats the cancer of the colon or rectum. It was found in the research that fucoidan stops the occurrence of fatigue in colorectal cancer patients in chemotherapy.   

Fatigue is dangerous  for the human body and it has been observed that fatigue reduces the individual resources of the patients. It also affects the nutritional status of the individual, and has a negative effect on the bone density of the therapy of cancer. It has been seen that fatigue is present in more than 30% patients of chemotherapy. The grade 2 and 3 fatigue was found in 60% of colorectal cancer patients with chemotherapy, in this study. Fatigue was also treated by the use of antidepressants. The study showed that patients who received fucoidan were able to go through the pain of prolonged chemotherapy without fatigue. But fucoidan didn’t affect the other adverse side effects of anti-cancer drugs. But the problem is that the main mechanism which explains the chemotherapy-induced fatigue is yet to be determined and there are no treatment currently available for alleviating the symptoms.

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